BLOG • November 14, 2025 • 15 min read
What Modern Science Now Validates
In 2015, the FDA approved a cancer therapy that works by applying specific electromagnetic frequencies to tumors. In 2023, they approved another. Neither mentions Royal Raymond Rife. But both validate the principle he investigated ninety years ago.
Royal Rife spent decades in his San Diego laboratory, sitting for up to 48 hours at a time before his microscope, methodically testing frequencies until he found the ones that destroyed specific pathogens. He called these frequencies "Mortal Oscillatory Rates" — the resonant frequency at which each organism would shatter, like a wine glass shattered by an opera singer's voice.
The medical establishment dismissed this as pseudoscience. They destroyed his laboratory, bankrupted his company, and erased him from history.
Now, in the 21st century, the FDA has approved therapies that work on exactly the same principle — and they're saving lives.
Tumor Treating Fields: The First Vindication
In 2011, the FDA approved a device called the NovoTTF-100A, marketed as Optune. It treats glioblastoma — the deadliest form of brain cancer — by applying alternating electric fields at a specific frequency: 200 kilohertz.
The principle is remarkably similar to what Rife described. Cancer cells divide rapidly, and during division, they are vulnerable. The electric fields disrupt the formation of the mitotic spindle — the cellular machinery that pulls chromosomes apart during cell division. The fields also interfere with septin proteins during cytokinesis, the final stage of cell division. The result: cancer cells die or stop dividing.
Healthy cells, which divide much more slowly, are largely unaffected.
The Numbers
The pivotal EF-14 trial, published in JAMA in 2017, studied 695 newly diagnosed glioblastoma patients:
(vs 16 months control)
(vs 31% control)
(vs 5% control)
Let those numbers sink in. A therapy using electromagnetic frequencies — not chemotherapy, not radiation, not surgery — nearly tripled the five-year survival rate for one of the most lethal cancers known to medicine.
The FDA has since approved TTFields for malignant pleural mesothelioma (2019) and metastatic non-small cell lung cancer (2024). Different cancers require different frequencies: 200 kHz for glioblastoma, 150 kHz for mesothelioma.
Rife would have recognized this immediately. He spent years cataloguing the specific frequencies for different organisms. The principle is identical: frequency specificity matters.
TheraBionic: Even Closer to Rife's Method
In September 2023, the FDA approved an even more remarkable device. TheraBionic P1 treats hepatocellular carcinoma — primary liver cancer — using amplitude-modulated radiofrequency fields.
The technical specifications read like a description of Rife's work:
- A carrier frequency of 27.12 MHz
- Tumor-specific modulation frequencies ranging from 0.01 Hz to 150 kHz
- Three one-hour treatment sessions per day
- Delivery via an antenna placed on the patient's tongue
The mechanism is particularly striking. The therapy activates specific calcium channels (Cav3.2) that act as "antennae" for the radio signals. This triggers a cascade that causes cancer cells to differentiate into harmless scar tissue — while leaving normal liver cells completely unaffected.
Cancer cells respond to the frequency. Healthy cells do not.
This is precisely what Rife claimed: that each pathogen has a specific resonant frequency that destroys it while leaving healthy tissue untouched. The mainstream medical establishment said this was impossible. The FDA just approved it.
The Science Behind the Resonance
Modern research has begun to explain why frequency-based therapies work. A 2024 study from Rice University demonstrated what they call "molecular jackhammers" — aminocyanine molecules that vibrate at 40 trillion oscillations per second when exposed to near-infrared light.
These vibrations are so intense that they physically rupture cancer cell membranes. In laboratory tests, they achieved 99% destruction of melanoma cells. In mice with melanoma tumors, 50% were completely cancer-free after treatment.
The principle is mechanical resonance — the same phenomenon that lets an opera singer shatter a glass. The same principle Rife described in the 1930s.
The Anthony Holland Research
Dr. Anthony Holland, a music professor and researcher at Skidmore College, has been investigating frequency-specific cancer destruction for over a decade. His TEDx talk, "Shattering Cancer with Resonant Frequencies," has been viewed millions of times.
His laboratory research, published as a preprint in 2023, demonstrated 38% inhibition of acute lymphocytic leukemia cells using oscillating pulsed electric fields at 160 kHz — and up to 72% inhibition using a specific combination of frequencies.
The research remains preliminary and has not been tested in humans. But it demonstrates that the principle continues to show results.
What Changed?
The physics hasn't changed. The principle that Rife demonstrated in the 1930s is the same principle that underlies TTFields and TheraBionic today. What changed was who was doing the research.
Novocure, the company behind TTFields, has a market capitalization of billions of dollars. TheraBionic received FDA Breakthrough Device Designation. These are institutional players with the resources to navigate regulatory approval, conduct large-scale clinical trials, and survive the decades-long process of bringing a medical device to market.
Rife was a lone researcher in a San Diego laboratory. When the medical establishment decided to destroy him, he had no institutional protection.
The Frequencies Are Real
Consider what we now know from FDA-approved research:
- Frequency specificity is real. Different cancers respond to different frequencies. TTFields uses 200 kHz for glioblastoma but 150 kHz for mesothelioma. TheraBionic uses tumor-specific modulation frequencies.
- Selective targeting is real. Both TTFields and TheraBionic affect cancer cells while leaving healthy tissue unharmed. This is not chemotherapy's carpet-bombing approach — it's precision medicine.
- Non-thermal mechanisms are real. These therapies work through electromagnetic interaction with cellular structures, not by heating tissue. The energy levels are far below what would cause thermal damage.
- The effects are measurable and reproducible. Large-scale clinical trials with hundreds of patients have demonstrated statistically significant improvements in survival.
Royal Rife claimed all of this ninety years ago. He was called a quack. His laboratory was destroyed. His associates were persecuted. His name was erased from medical history.
Now the FDA approves devices based on the same principles, and the companies that make them are worth billions.
The Missing Acknowledgment
Search the scientific literature on TTFields. Read the FDA approval documents for TheraBionic. Nowhere will you find the name Royal Raymond Rife.
This is not surprising. Acknowledging Rife would raise uncomfortable questions. If a lone researcher in the 1930s discovered a principle that is now saving lives, what happened to those ninety years? How many people died of cancers that might have been treated differently?
The Smithsonian Institution published specifications of Rife's microscope in 1944. Science magazine covered his work in 1931 and 1932. The San Diego Tribune reported on his cancer treatment in 1938. The evidence that he existed and did serious research is documented in institutional archives.
But history is written by the victors. And the medical establishment won.
What This Means
We are not claiming that Rife's specific frequencies work, or that modern "Rife machines" are effective. No rigorous clinical trials have been conducted on these devices.
What we are claiming is simpler and more important: the principle that Rife investigated — that specific electromagnetic frequencies can selectively destroy cancer cells — is now FDA-approved and saving lives.
The question is no longer whether frequency-based cancer therapy works. The FDA has answered that question. The question is whether Royal Raymond Rife discovered this principle decades before the modern research, and whether the destruction of his work delayed the development of these therapies by generations.
The historical record suggests he did. And the record of what was done to him suggests that the delay was not accidental.